https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Blood-brain barrier disruption in atrial fibrillation: a potential contributor to the increased risk of dementia and worsening of stroke outcomes? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45212 Wed 26 Oct 2022 15:56:18 AEDT ]]> Critical role for iron accumulation in the pathogenesis of fibrotic lung disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41157 Wed 15 Feb 2023 10:57:18 AEDT ]]> Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30189 Hfe−/−xTfr2mut mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family ‘neurodegeneration with brain iron accumulation’ (NBIA). Expanded data mining and ontological analyses have now identified additional myelin-related transcriptome changes in response to brain iron loading. Concordance between the mouse transcriptome changes and human myelin-related gene expression networks in normal and NBIA basal ganglia testifies to potential clinical relevance. These analyses implicate, among others, genes linked to various rare central hypomyelinating leukodystrophies and peripheral neuropathies including Pelizaeus-Merzbacher-like disease and Charcot-Marie-Tooth disease as well as genes linked to other rare neurological diseases such as Niemann-Pick disease. The findings may help understand interrelationships of iron and myelin in more common conditions such as hemochromatosis, multiple sclerosis and various psychiatric disorders.]]> Wed 11 Apr 2018 16:58:00 AEST ]]> Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41158 Thu 28 Jul 2022 09:27:19 AEST ]]> Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer's disease etiology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38383 Mon 29 Jan 2024 17:45:07 AEDT ]]> The relationship of iron and amyloid: insights from a new mouse model of iron loading and amyloidosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36313 Mon 23 Aug 2021 12:41:47 AEST ]]>